Abstract
Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D2A, D3) and 5HT1A receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D2 > D3.
MeSH terms
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Animals
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CHO Cells
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Cricetinae
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Humans
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Mice
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Piperazines / chemistry*
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Piperazines / metabolism
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Piperazines / pharmacology*
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Radioligand Assay
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Receptors, Dopamine D2 / drug effects*
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Receptors, Dopamine D2 / metabolism
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Receptors, Dopamine D3
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin / metabolism
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Receptors, Serotonin, 5-HT1
Substances
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DRD3 protein, human
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Drd3 protein, mouse
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Piperazines
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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phenylpiperazine